Journal
VACCINE
Volume 33, Issue 31, Pages 3682-3688Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2015.06.031
Keywords
Influenza vaccines; Immunity, Humoral; Models, Statistical; Aged; Adult; Age factors
Categories
Funding
- National Institute of Allergy And Infectious Diseases of the National Institutes of Health [U01AI089859]
- National Center for Advancing Translational Sciences (CCaTS) [UL1 TR000135]
Ask authors/readers for more resources
Greater understanding of the factors associated with a protective response to influenza vaccine in older adults could have tremendous public health benefits. We studied 158 participants age 50-74 years vaccinated with 2010-2011 inactivated influenza vaccine and performed innate immunity and humoral immunity assays directed against influenza A/California/2009 (H1N1) as measured through hemagglutination inhibition (HAI), microneutralization, and B cell ELISPOT at days 0, 3, and 28 postvaccination. We report the results of statistical modeling using Day 3 cytokines, chemokines, and innate cell populations to model Day 0 to Day 28 HAI seroconversion, viral neutralization seroconversion, and B cell ELISPOT results. (C) 2015 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available