Journal
VACCINE
Volume 33, Issue 36, Pages 4422-4429Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2015.06.101
Keywords
Vaccination; Immunization; Obesity; Immunity; Communicable diseases
Categories
Funding
- National Institute of Allergy And Infectious Diseases of the National Institutes of Health [U01AI089859]
- National Center for Advancing Translational Sciences (NCATS) [UL1 TR000135]
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Despite the high success of protection against several infectious diseases through effective vaccines, some sub-populations have been observed to respond poorly to vaccines, putting them at increased risk for vaccine-preventable diseases. In particular, the limited data concerning the effect of obesity on vaccine immunogenicity and efficacy suggests that obesity is a factor that increases the likelihood of a poor vaccine-induced immune response. Obesity occurs through the deposition of excess lipids into adipose tissue through the production of adipocytes, and is defined as a body-mass index (BMI) >= 30 kg/m(2). The immune system is adversely affected by obesity, and these immune consequences raise concern for the lack of vaccine-induced immunity in the obese patient requiring discussion of how this sub-population might be better protected. (C) 2015 Elsevier Ltd. All rights reserved.
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