Journal
ARCHIVES OF VIROLOGY
Volume 161, Issue 3, Pages 705-710Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-015-2719-1
Keywords
Canine parvovirus; Virus-like particles; Vaccine
Categories
Funding
- Innovation Fund for Technology Based Firms of Jilin Province [SC201407103]
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An optimized VP2 gene from the current prevalent CPV strain (new CPV-2a) in China was expressed in a baculovirus expression system. It was found that the VP2 proteins assembled into virus-like particles (VLPs) with antigenic properties similar to those of natural CPV and with an especially high hemagglutination (HA) titer (1:2(20)). Dogs intramuscularly or orally immunized with VLPs produced antibodies against CPV with > 1:80 hemagglutination inhibition (HI) units for at least 3 months. The CPV VLPs could be considered for use as a vaccine against CPV or as a platform for research on chimeric VLP vaccines against other diseases.
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