Journal
ARCHIVES OF VIROLOGY
Volume 161, Issue 1, Pages 125-133Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-015-2655-0
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- JSPS KAKENHI [25292183]
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Feline infectious peritonitis (FIP) is a fatal disease of domestic and wild felidae that is caused by feline coronavirus (FCoV). FCoV has been classified into types I and II. Since type I FCoV infection is dominant in the field, it is necessary to develop antiviral agents and vaccines against type I FCoV infection. However, few studies have been conducted on type I FCoV. Here, we compare the effects of cholesterol on types I and II FCoV infections. When cells were treated methyl-beta-cyclodextrin (M beta CD) and inoculated with type I FCoV, the infection rate decreased significantly, and the addition of exogenous cholesterol to M beta CD-treated cells resulted in the recovery of the infectivity of type I FCoV. Furthermore, exogenous cholesterol increased the infectivity of type I FCoV. In contrast, the addition of M beta CD and exogenous cholesterol had little effect on the efficiency of type II FCoV infection. These results strongly suggest that the dependence of infection by types I and II FCoV on cholesterol differs.
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