Journal
PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA
Volume 22, Issue 4, Pages 577-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.pmr.2011.08.002
Keywords
Traumatic brain injury; Metabolic cascade; Activation; Plasticity; Pediatrics
Categories
Funding
- Child Neurology Foundation/Winokur Family Foundation
- Today's and Tomorrow's Children Fund
- UCLA Brain Injury Research Center
- [NS27544]
- [NS057420]
- [NS06190]
Ask authors/readers for more resources
Mild traumatic brain injury, especially sport-related concussion, is common among young persons. Consequences of transient pathophysiologic dysfunction must be considered in the context of a developing or immature brain, as must the potential for an accumulation of damage with repeated exposure. This review summarizes the underlying neurometabolic cascade of concussion, with emphasis on the young brain in terms of acute pathophysiology, vulnerability, alterations in plasticity and activation, axonal injury, and cumulative risk from chronic, repetitive damage, and discusses their implications in the context of clinical care for the concussed youth, highlighting areas for future investigation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available