Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 16, Issue 32, Pages 17163-17171Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cp01693a
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Funding
- Indian Institute of Science Education and Research (USER), Pune
- Council of Scientific and Industrial Research (CSIR)
- USER Pune
- Department of Science and Technology (DST), India [SR/S1/PC/0054/2010]
- University of Bologna
- MIUR (PRIN) [Prot. 2010ERFKXL_001]
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In this study, we have determined the structure of a medicinally important molecule saligenin (2-hydroxybenzyl alcohol) using UV, IR and microwave absorption spectroscopy in a supersonic jet combined with ab initio calculations. The structure of the only observed conformer of saligenin corresponds to the global minimum on the conformational surface. The observed structure is stabilized by an intramolecular strong O-H...O hydrogen bonding as well as a very weak interaction. The hydrogen bond is formed through phenolic O-H as the hydrogen bond donor and benzylic OH as the hydrogen bond acceptor white the O-H...pi interaction is through benzylic OH as the hydrogen bond donor and phenyl group as the hydrogen bond acceptor. It has been observed that the benzylic OH stretching frequency in saligenin is more red-shifted compared to that in benzyl alcohol as the strong O-H...O interaction present in saligenin acts on the benzylic O-H group. In fact, there is a subtle interplay among the strong O-H...O hydrogen bond, weak O-H...pi it interaction, and steric effects arising from the ortho substitution of the OH group in benzyl alcohol. This fine-tuning of multiple interactions very often governs the specific structures of biomolecules and materials.
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