Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 15, Issue 27, Pages 11454-11460Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cp50916h
Keywords
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Funding
- Japan Society for the Promotion of Science (JSPS) [23560925]
- Innovation School program by the National Institute of Advanced Industrial Science and Technology
- Grants-in-Aid for Scientific Research [23560925] Funding Source: KAKEN
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We investigated the drug releasing behavior of a novel nanocarrier system, utilizing a peptide to act as a nanogate to the mesopore, on a mesoporous silica nanoparticle. The surface peptide on mesoporous silica displayed pH-dependant mesopore cap-uncap switching behavior, enabled by the reversible beta-sheet-to-random coil conformational transition resulting from slight pH changes between 8.0 and 6.0. The peptide adopted a beta-sheet structure under weakly basic conditions (pH 8.0) and a random coil conformation under weakly acidic conditions (pH 6.0). We demonstrated the pH-dependant regulation of the material's drug release property by the reversible conformational transition of the surface peptide. Under basic pH conditions, the drug release from the nanocarrier was significantly inhibited. However, under acidic pH conditions, the drug in the mesopore was gradually released.
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