Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 15, Issue 28, Pages 11893-11899Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cp51215k
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Funding
- Fundacao para a Ciencia e a Tecnologia (FCT)
- FEDER through COMPETE [PTDC/QUI-BIQ/102827/2008, PTDC/QUI-BIQ/118076/2010]
- Portuguese National NMR Network (RNRMN)
- FCT [REEQ/1062/CTM/2005, REDE/1512/RME/2005, SFRH/BD/45384/2008]
- CEMUP
- Fundação para a Ciência e a Tecnologia [PTDC/QUI-BIQ/102827/2008, SFRH/BD/45384/2008] Funding Source: FCT
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Graft copolymers of chitosan and maltodextrin were synthesized by reductive amination of a low molecular weight chitosan. The degree of substitution is 70% or above, as quantified by nuclear magnetic resonance spectroscopy, at molar ratios of chitosan glucosamine units and maltodextrin of 1 : 1 and 1 : 5. The high substitution degree generates a water-soluble compound at pH 7.4 by reducing the amino groups of chitosan. In addition, the copolymer self-assembles into spherical nanoparticles with diameters of about 300 nm. The mass polymer/DNA ratios at the isoelectric point are within the range of 3-3.5 for chitosan-maltodextrin nanoparticles as determined by electrophoretic mobility measurements. These results confirm that DNA interacts efficiently with the copolymer nanoparticles indicating a potential application of the system for DNA delivery.
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