Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 14, Issue 42, Pages 14489-14491Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cp42920a
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Funding
- Leverhulme Trust [F/00114/BH]
- University of Nottingham
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The sacoglossan mollusc-derived metabolite, tridachiahydropyrone (3), and its proposed biosynthetic precursors (1 and 2) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively localised at cell membranes and outline a binding scheme that accommodates the observed data. The possibility that localised lipid domains within the membrane have an effect on the localisation is also addressed.
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