Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 13, Issue 38, Pages 16928-16940Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cp21868a
Keywords
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Funding
- Ministry of Education, Science, Sports and Culture in Japan [20107003]
- [18205002]
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A recently developed method to monitor reaction kinetics of intermolecular interaction is presented in this perspective. This method is based on time-dependent diffusion coefficient measurements using the pulsed laser induced transient grating technique. Using this method, time dependent biomolecular interactions, such as transient association and dissociation reactions in solution, have been successfully detected in real time. The principles and particular applications are described. In particular, unique features of this time-dependent diffusion coefficient method are emphasized by comparison with other techniques.
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