Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 12, Issue 22, Pages 5779-5785Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cp00157k
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Funding
- National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health
- National Institutes of Health
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [ZIADK029029] Funding Source: NIH RePORTER
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We evaluate the feasibility of 1 H nuclear magnetic resonance (NMR) imaging with sub-micron voxel dimensions using a combination of low temperatures and dynamic nuclear polarization (DNP). Experiments are performed on nitroxide-doped glycerol-water at 9.4 T and temperatures below 40 K, using a 30 mW tunable microwave source for DNP. With DNP at 7 K, a 0.5 mu L sample yields a (1)H NMR signal-to-noise ratio of 770 in two scans with pulsed spin-lock detection and after 80 db signal attenuation. With reasonable extrapolations, we infer that (1)H NMR signals from 1 mu m(3) voxel volumes should be readily detectable, and voxels as small as 0.03 mu m(3) may eventually be detectable. Through homonuclear decoupling with a frequency-switched Lee-Goldburg spin echo technique, we obtain 830 Hz (1)H NMR linewidths at low temperatures, implying that pulsed field gradients equal to 0.4 G/d or less would be required during spatial encoding dimensions of an imaging sequence, where d is the resolution in each dimension.
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