Journal
ARCHIVES OF TOXICOLOGY
Volume 89, Issue 12, Pages 2197-2205Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00204-015-1633-3
Keywords
Cisplatin; Nephrotoxicity; Apoptosis; Kidney; DNA damage; P53
Categories
Funding
- National Natural Science Foundation of China [81430017]
- National Basic Research Program of China 973 Program [2012CB517601]
- National Institutes of Health and Department of Veterans Administration of USA
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Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and death, resulting in acute kidney injury (AKI). Recent studies have suggested that DNA damage and the associated DNA damage response (DDR) are an important pathogenic mechanism of AKI following cisplatin treatment. Activation of DDR may lead to cell cycle arrest and DNA repair for cell survival or, in the presence of severe injury, kidney cell death. Modulation of DDR may provide novel renoprotective strategies for cancer patients undergoing cisplatin chemotherapy.
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