Journal
PHYSICAL BIOLOGY
Volume 9, Issue 1, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1478-3975/9/1/016004
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Funding
- NIH from National Cancer Institute [R01CA125653, U54CA143906]
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Sampling circulating tumor cells (CTCs) from peripheral blood is ideally accomplished using assays that detect high numbers of cells and preserve them for downstream characterization. We sought to evaluate a method using enrichment free fluorescent labeling of CTCs followed by automated digital microscopy in patients with non-small cell lung cancer. Twenty-eight patients with non-small cell lung cancer and hematogenously seeded metastasis were analyzed with multiple blood draws. We detected CTCs in 68% of analyzed samples and found a propensity for increased CTC detection as the disease progressed in individual patients. CTCs were present at a median concentration of 1.6 CTCs ml(-1) of analyzed blood in the patient population. Higher numbers of detected CTCs were associated with an unfavorable prognosis.
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