Journal
PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS
Volume 250, Issue 5, Pages 1020-1027Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/pssb.201248524
Keywords
chalcogenides; fibre optics; in vivo sensing; mid-infrared; skin cancer
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Funding
- Royal Academy of Engineering/Leverhulme Trust
- Medical Research Council [G0701869]
- NEAT (New and Emerging Applications of Technology) [FSG028]
- STFC [SM2751]
- Royal Society [JP100296]
- European Commission (MINERVA)
- Medical Research Council [G0701869] Funding Source: researchfish
- National Institute for Health Research [FSG028] Funding Source: researchfish
- MRC [G0701869] Funding Source: UKRI
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After an introduction to the mid-infrared (IR) spectral region, the tremendous significance of mid-IR spectroscopic sensing is highlighted. The remarkable progress made towards mid-IR spectral in vitro mapping of tissue and cancer detection is reviewed, with emphasis on diagnosis of skin cancer. The status quo of chalcogenide glass mid-IR fibre optics and photonics for meeting opportunities for remote mid-IR sensing in general, and in in vivo cancer detection in particular, is assessed. Raman spectroscopy is a sister technique to mid-IR spectroscopy. The current success of Raman spectroscopy in medical diagnosis is appraised, with particular emphasis on Raman spectral imaging of tissue towards skin cancer diagnosis in vivo, based on a silica-glass fibreoptic sensor-head. The challenges to be met in chalcogenide glass science and technology towards facilitating analogous fibreoptic diagnostics based on mid-IR spectroscopy are addressed.
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