Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 41, Issue 1, Pages 235-250Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2014.05.019
Keywords
Ultrasound tomography; Speed of sound; Aberration correction; Diagnostic imaging; Multimodal imaging
Funding
- Swiss National Science Foundation, through the career development scheme Ambizione [PZ00 P3_142585]
- NF Project [205320-144443]
- European Community's Seventh Framework Programme (FP7) [318067]
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The limitations of diagnostic echo ultrasound have motivated research into novel modalities that complement ultrasound in a multimodal device. One promising candidate is speed of sound imaging, which has been found to reveal structural changes in diseased tissue. Transmission ultrasound tomography shows speed of sound spatially resolved, but is limited to the acoustically transparent breast. We present a novel method by which speed-of-sound imaging is possible using classic pulse-echo equipment, facilitating new clinical applications and the combination with state-of-the art diagnostic ultrasound. Pulse-echo images are reconstructed while scanning the tissue under various angles using transmit beam steering. Differences in average sound speed along different transmit directions are reflected in the local echo phase, which allows a 2-D reconstruction of the sound speed. In the present proof-of-principle study, we describe a contrast resolution of 0.6% of average sound speed and a spatial resolution of 1 mm (laterally) x 3 mm (axially), suitable for diagnostic applications. (C) 2015 World Federation for Ultrasound in Medicine & Biology.
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