Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 41, Issue 11, Pages 2806-2819Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2015.06.007
Keywords
Acoustic radiation force; Shear wave speed; Acoustic radiation force impulse imaging; Cutaneous sclerotic diseases
Funding
- NIH [EB002132]
- Duke Skin Research Center, Dermatology Foundation
- Pinnell Center for Investigative Dermatology Translational and Innovative Research Support Program
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In this study, acoustic radiation force impulse (ARFI) and shear wave elasticity imaging (SWEI) were applied to the skin to investigate the feasibility of their use in assessing sclerotic skin diseases. Our motivation was to develop a non-invasive imaging technology with real-time feedback of sclerotic skin disease diagnosis. This paper shows representative results from an ongoing study, recruiting patients with and without sclerosis. The stiffness of the imaged site was evaluated using two metrics: mean ARFI displacement magnitude and bulk shear wave speed inside the region of interest (ROI). In a subject with localized graft versus host disease (GVHD), the mean ARFI displacement inside sclerotic skin was 61% lower (p < 0.01) and shear wave speed 128% higher (p < 0.005) compared to those in normal skin-indicating stiffer mechanical properties in the sclerotic skin. This trend persisted through disease types. We conclude ARFI and SWEI can successfully differentiate sclerotic lesions from normal dermis. (E-mail: jinylee88@gmail.com) (C) 2015 World Federation for Ultrasound in Medicine & Biology.
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