Journal
ARCHIVES OF TOXICOLOGY
Volume 89, Issue 9, Pages 1497-1522Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00204-015-1519-4
Keywords
Acetaminophen; MicroRNA; Proteomics; Metabolomics; Biomarkers
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Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver necrosis and liver failure. APAP-induced liver injury is associated with glutathione depletion, the formation of APAP protein adducts, the generation of reactive oxygen and nitrogen species and mitochondrial injury. The systems biology omics technologies (transcriptomics, proteomics and metabolomics) have been used to discover potential translational biomarkers of liver injury. The following review provides a summary of the systems biology discovery process, analytical validation of biomarkers and translation of omics biomarkers from the nonclinical to clinical setting in APAP-induced liver injury.
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