Journal
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
Volume 30, Issue 5, Pages 588-591Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejmp.2014.04.009
Keywords
Ion beam therapy; RBE; Hypofractionation; SBRT
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An important advantage for the application of carbon ion beams in tumour therapy is their increased relative biological effectiveness (RBE) as compared to conventional photon radiation. Since RBE among other factors depends on the dose level, the precise knowledge of the RBE dependence on the dose is of particular importance for the comparison of different fractionation schemes, involving different doses per fraction. Here we describe some general properties of the RBE vs. dose dependence, which are determined using a simple modelling approach based on the linear-quadratic model as well as a more sophisticated predictive model for the description of RBE. We show that for both approaches the systematic dependence of RBE on the cell or tissue type as characterized by the alpha/beta-ratio of the photon linear quadratic parameters is expected to be inverted at high doses as compared to low doses. We demonstrate that this inversion is not a model specific feature, but a rather generic feature resulting from the linear-quadratic shape of dose response curves and the correlation between RBE and the photon alpha/beta-ratio. The results are discussed with respect to other modelling approaches and to their implications for clinical applications of carbon ion beams using hypofractionated treatment schedules. (C) 2014 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
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