Journal
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
Volume 25, Issue 1, Pages 1-11Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejmp.2008.10.001
Keywords
Positron emission tomography; Time of flight; TOF reconstruction; TOF PET; Scintillation detectors; TOF gain; Signal-to-noise ratio
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After a brief review of the history of time-of-flight (TOF) positron emission tomography (PET) instrumentation from the 1980s to present, the principles of TOF PET are introduced, the concept of time resolution and its effect on TOF gain in signal-to-noise ratio (SNR) are discussed. The factors influencing the time resolution of a TOF PET scanner are presented, with focus on the intrinsic properties of scintillators of particular interest for TOF PET. Finally, some open issues, challenges and achievements of today's TOF PET reconstruction are reviewed: the structure of the data organization, the choice of analytical. or iterative method, the recent experimental assessment of TOF image quality, and the most promising applications of TOF PET. (C) 2008 Associazione Itatiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
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