Journal
ULTRASONICS SONOCHEMISTRY
Volume 23, Issue -, Pages 81-92Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ultsonch.2014.10.006
Keywords
Sonication; Polyelectrolytes; Nanoemulsion template; Nanocapsules; Microscopy
Categories
Funding
- National Natural Science Foundation of China [31071602]
- Agricultural Science and Technology Achievements Transformation Project [2011GB23600012]
- Academic Program Development of Jiangsu Higher Education Institutions
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In this study, biodegradable polymeric nanocapsules were prepared by sequential deposition of food-grade polyelectrolytes through the self-assembling process onto the oil (medium chain triglycerides) droplets enriched with curcumin (lipophilic bioactive compound). Optimum conditions were used to prepare ultrasound-assisted nanoemulsions stabilized by octenyl-succinic-anhydride (OSA)-modified starch. Negatively charged droplets (-39.4 +/- 1.84 mV) of these nanoemulsions, having a diameter of 142.7 +/- 0.85 nm were used as templates for the fabrication of nanocapsules. Concentrations of layerforming cationic (chitosan) and anionic (carboxymethylcellulose) biopolymers were optimized based on the mean droplet/particle diameter (MDD/MPD), polydispersity index (PDI) and net charge on the droplets/capsules. Prepared core shell structures or nanocapsules, having MPD of 159.85 +/- 0.92 nm, were characterized by laser diffraction (DLS), C-potential (ZP), atomic force microscopy (AFM), transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM). Furthermore, physical stability of curcumin-loaded nanocapsules in suspension was determined and compared at different storage temperatures. This study may provide information regarding the formation of ultrasound-assisted polymeric nanocapsules from the nanoemulsion templates which could be helpful in the development of delivery systems for lipophilic food bioactives. (C) 2014 Elsevier B.V. All rights reserved.
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