Journal
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
Volume 7, Issue 2, Pages 61-75Publisher
ELSEVIER
DOI: 10.1016/j.pdpdt.2010.02.001
Keywords
Photosensitizers; Photodynamic therapy; Photofrin (R); Classification; Review
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A myriad of naturally occurring and synthetic structures are capable of transferring the energy of light. Few, however, allow for this energy transfer to enable a type II photochemical reaction which, as currently practiced, is a fundamental component of photodynamic therapy. Even fewer of these agents, aptly termed photosensitizers, have found success in the treatment of patients. This review will focus on the oncologic photosensitizers that have come to clinical trial with outcomes published in peer reviewed journals. Based on a clinical orientation the qualities of successful photosensitizers will be examined, how current drugs fare and potential future options explored. (C) 2010 Elsevier B.V. All rights reserved.
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