Journal
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
Volume 24, Issue 3, Pages 147-149Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0781.2008.00351.x
Keywords
adult T-cell leukemia; chronic actinic dermatitis; Southern blot analysis
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A patient with chronic actinic dermatitis showed a leukocytosis with peripheral atypical lymphocytes. Histology of cutaneous eruptions disclosed a dense infiltrate of lymphocytes mixed with large hyperchromatic cells in the dermis and Pautrier-like microabscesses in the epidermis. However, clonal rearrangements of the T-cell receptors were not detected. On the other hand, monoclonal integration of human T-cell lymphotrophic virus type I provirus was found in the peripheral lymphocytes. In the present case, pseudolymphomatous changes occurred in association with adult T-cell leukemia. Southern blot analyses were useful for the correct diagnosis.
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