Journal
PHOTOCHEMISTRY AND PHOTOBIOLOGY
Volume 86, Issue 2, Pages 431-437Publisher
WILEY
DOI: 10.1111/j.1751-1097.2009.00652.x
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Funding
- Faculty Research Grants [FRG/07-08/I-14, FRG/07-08/I-19]
- University Fellowship of Hong Kong Baptist University
- Research Grants Council of Hong Kong [HKBU 2458/06M]
- National Natural Science Foundation of China [10774027]
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While semiconductor quantum dots produce little singlet oxygen, they may undergo Type I photoreactions to produce other reactive oxygen species (ROS) to kill cells. CdTe quantum dots coated with thioglycolic acid were used to test that possibility. Some thiol ligands were purposely removed to regenerate the surface electron traps that were passivated by the ligand. This allowed photoinduced electrons to dwell on the surface long enough to be gathered by nearby oxygen molecules to produce ROS. The photocytotoxicity of these quantum dots was tested on nasopharyngeal carcinoma cells. Photokilling was shown to be drug and light dose dependent. Using 0.6 mu m quantum dots for incubation and 4.8 J cm-2 for irradiation, about 80% of the cells were annihilated. These quantum dots promised to be potent sensitizers for photoannihilation of cancer cells.
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