Journal
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
Volume 13, Issue 8, Pages 1137-1145Publisher
SPRINGERNATURE
DOI: 10.1039/c3pp50376c
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Funding
- FAPESP (Sao Paulo Research Foundation) [2008/57858-9, 2009/17476-2, 2011/13993-2, 2011/19720-8, 2013/06532-4, 1998/14270-8]
- CNPq [573587/2008-6]
- CAPES
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Chlorin-e6 (chl-e6) and a hydrogenated derivative (chl-e6H) were semi-synthesized, and their photophysical properties and photodynamic activity against Escherichia coli, Staphylococcus aureus and Candida albicans evaluated. Methyl pheophorbide-a (Mepheo-a) was obtained from S. maxima using methanolic extraction with acid catalysis (CH3OH-H2SO4). Chlorin-e6 was prepared from Mepheo-a by basic hydrolysis with H2O-acetone and NaOH. Hydrogenated Chlorin-e6 was synthesized by a similar procedure starting from the hydrogenated methyl pheophorbide-a (Mepheo-aH). Photophysical studies were performed in order to determine the singlet oxygen quantum yield of chl-e6H which is higher than that of chl-e6. The microorganism inactivation of chl-e6 and chl-e6H was investigated at two concentrations and three fluence levels. Both chl-e6 and chl-e6H showed microorganism inactivation against Gram-positive bacteria and a fungus.
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