Journal
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
Volume 10, Issue 5, Pages 649-652Publisher
SPRINGERNATURE
DOI: 10.1039/c0pp00354a
Keywords
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Funding
- NATIONAL CANCER INSTITUTE [R01CA098156, P01CA055791] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA098156, P01 CA055791] Funding Source: Medline
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Photodynamic therapy (PDT) is an FDA-approved modality for the treatment of early-stage disease and palliation of late-stage disease. Pre-clinical studies using mouse models and clinical studies in patients have demonstrated that PDT is capable of influencing the immune system. The effect of PDT on the generation of anti-tumor immunity is regimen-dependent and is tightly linked to the degree and nature of inflammation induced by PDT. However, the precise mechanism underlying PDT-regulated adaptive anti-tumor immunity remains unclear. This review will focus on the current knowledge of immune regulation by PDT.
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