Journal
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
Volume 8, Issue 1, Pages 37-44Publisher
SPRINGERNATURE
DOI: 10.1039/b810921d
Keywords
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Funding
- Spanish MEC [CTQ2005-08016003]
- GVA [GV/2007/277, ARVIV/2007/079, ARVIV/2007/081]
- F. Caixa Castello-UJI [P1.1A200705]
- Cancer Research UK [C22031/A7097]
- MEC (Ramon y Cajal Program)
- MEC (FPI)
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Photogeneration of singlet oxygen (O-1(2)) by rose bengal is improved through the use of a porous monolithic polymer (PMP) as a support, as compared to a classic gel-type resin matrix. This type of monolithic polymeric matrix can be made at a multigram scale in quantitative yields enabling the preparation of large amounts of supported photosensitizer at low cost. The singlet oxygen induced oxidation of 9,10-diphenylanthracene has been used as a benchmark reaction, and a comparative study using rose bengal in solution, entrapped within gel-type derived polymer and entrapped within a porous monolithic polymer (PMP) has been performed. The enhanced photoreactivity of the PMP-rose bengal conjugates has been utilised for the successful photodynamic therapy (PDT) of melanoma cells.
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