Journal
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
Volume 190, Issue 1, Pages 45-52Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10426507.2014.919295
Keywords
metal-free reaction; thiourea; Asymmetric sulfides
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The synthesis of sulfides is important in various fields. This paper reports an efficient, odorless, and viable protocol for the base-mediated synthesis of benzyl alkyl sulfides using thiourea. The reactions were carried out under transition-metal-free conditions, showing yields of asymmetric sulfides higher than 80%. Tertiary alkyl halides and aryl halides do not react with thiourea under formation of the corresponding isothiouronium salts; however, 5-bromopyrimidine and 2-bromopyrimidine lead to yields of 79.2% and 87.6%, respectively. This method is of significant importance from the both environmental and economic, green chemistry points of view.
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