Journal
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
Volume 187, Issue 4, Pages 544-553Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10426507.2011.631644
Keywords
3,4-Dihydropyrimidin-2(1H)-one; activated charcoal; H2SO4; Biginelli synthesis
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Funding
- Research Council of Urmia University
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Various 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) and their sulfur derivatives were efficiently synthesized by a one-pot cyclocondensation reaction of aromatic and aliphatic aldehydes, beta-dicarbonyl compounds and urea (or thiourea) in the presence of sulfuric acid immobilized on activated charcoal (133% w/w). The reactions were carried out in refluxing n-hexane-acetonitrile (2.5:0.5 mL) within 5-150 min to give 3,4-dihydropyrimidinones (or thiones) in high to excellent yields (81-97%).
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