Journal
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
Volume 184, Issue 10, Pages 2704-2719Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10426500802583504
Keywords
2-Aminobenzothiazole; biological activity; 2-chloro-3-formylquinoline; 1,3-cyclohexanedione; multicomponent reaction; thiazolo[2,3-b]quinazolinone
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A new series of 12-(2-chloro-6-quinoline-3-yl)-3,3,8-substituted-2,3,4,12-tetrahydro-benzo[4,5]thiazolo[2,3-b]quinazolin-1-ones 4 was synthesized in one pot by condensing various 2-chloro-3-formylquinolines 1, 2-amino-6-substituted-benzothiazoles 2, and 1,3-cyclohexanedione 3 in ethanol. All the compounds were characterized by IR, H-1 NMR, C-13 NMR spectra and elemental analysis. All the synthesized compounds were screened for their antibacterial activity against Grampositive bacterial species Bacillus cereus and Bacillus substilus, Gram-negative bacterial species Escherichia coli, and their fungicidal activity against Aspergillus niger, Fuserium oxisporum, and Rhizopus species.
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