Journal
TURKISH JOURNAL OF CHEMISTRY
Volume 39, Issue 1, Pages 179-193Publisher
Tubitak Scientific & Technological Research Council Turkey
DOI: 10.3906/kim-1408-72
Keywords
Alnustone-like compounds; MCF-7; breast cancer; estrogen receptor alpha; diarylheptanoids
Funding
- Ataturk University
- Turkish Academy of Sciences (TUBA-GEBIP)
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Alnustone-like compounds are promising inhibitors for estrogen receptor alpha (ER-alpha), which is a novel cancer therapeutic target. Therefore, 10 alnustone-like compounds with substituents at the phenyl rings were synthesized by condensation of 4-phenyl-2-butanones and cinnamaldehydes via in situ enamination. The compounds displayed either protective activity or inhibited cell growth and proliferation of human breast cancer cells. Molecular docking studies indicated that the synthesized compounds interact with ER-alpha efficiently. In this work, the protective and inhibitive roles of the synthesized compounds were related to their functional groups and to their binding mode of action on ER-alpha protein. The compounds are potential drug candidates as ER-alpha antagonists.
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