Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 369, Issue 1653, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2013.0526
Keywords
functional connectivity; resting-state; cortical networks; MRI; intrinsic connectivity
Categories
Funding
- Ashford Graduate Fellowship Fund
- Simons Foundation
- Athinoula A. Martinos Center for Biomedical Imaging [P41EB015896, S10RR021110, S10RR023401, S10RR019307]
- National University of Singapore
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Functional coupling across distributed brain regions varies across task contexts, yet there are stable features. To better understand the range and central tendencies of network configurations, coupling patterns were explored using functional MRI (fMRI) across 14 distinct continuously performed task states ranging from passive fixation to increasingly demanding classification tasks. Mean global correlation profiles across the cortex ranged from 0.69 to 0.82 between task states. Network configurations from both passive fixation and classification tasks similarly predicted task coactivation patterns estimated from meta-analysis of the literature. Thus, even across markedly different task states, central tendencies dominate the coupling configurations. Beyond these shared components, distinct task states displayed significant differences in coupling patterns in response to their varied demands. One possibility is that anatomical connectivity provides constraints that act as attractors pulling network configurations towards a limited number of robust states. Reconfigurable coupling modes emerge as significant modifications to a core functional architecture.
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