Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 369, Issue 1654, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2013.0601
Keywords
NMDA receptors; plasticity; D-serine; glycine; excitotoxicity
Categories
Funding
- HFSP
- Inserm
- FRM
- Conseil Regional d'Aquitaine
- LABEX BRAIN [ANR-10-LABX-43]
- Agence National de la Recherche
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N-methyl D-aspartate receptors (NMDARs) exist in different forms owing to multiple combinations of subunits that can assemble into a functional receptor. In addition, they are located not only at synapses but also at extrasynaptic sites. There has been intense speculation over the past decade about whether specific NMDAR subtypes and/or locations are responsible for inducing synaptic plasticity and excitotoxicity. Here, we review the latest findings on the organization, subunit composition and endogenous control of NMDARs at extrasynaptic sites and consider their putative functions. Because astrocytes are capable of controlling NMDARs through the release of gliotransmitters, we also discuss the role of the glial environment in regulating the activity of these receptors.
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