Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 368, Issue 1616, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2012.0322
Keywords
organohalide respiration; reductive dehalogenase; phylogenetics
Categories
Funding
- Government of Canada through NSERC
- Genome Canada
- Ontario Genomics Institute [2009-OGI-ABC-1405]
- Government of Ontario through the ORF-GL2 program
- United States Department of Defence through the Strategic Environmental Research and Development Program (SERDP) [ER-1586]
- The Netherlands Genomics Initiative through the Ecogenomics project
- The Netherlands Genomics Initiative through the ECOLINC project
- European Research Council (ERC)
- German Research Foundation [DFG-FOR1530]
- Biotechnology and Biological Sciences Research Council [BB/C00521X/1] Funding Source: researchfish
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Organohalide respiration is an anaerobic bacterial respiratory process that uses halogenated hydrocarbons as terminal electron acceptors during electron transport-based energy conservation. This dechlorination process has triggered considerable interest for detoxification of anthropogenic groundwater contaminants. Organohalide-respiring bacteria have been identified from multiple bacterial phyla, and can be categorized as obligate and non-obligate organohalide respirers. The majority of the currently known organohalide-respiring bacteria carry multiple reductive dehalogenase genes. Analysis of a curated set of reductive dehalogenases reveals that sequence similarity and substrate specificity are generally not correlated, making functional prediction from sequence information difficult. In this article, an orthologue-based classification system for the reductive dehalogenases is proposed to aid integration of new sequencing data and to unify terminology.
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