Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 368, Issue 1611, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rstb.2012.0033
Keywords
singe molecule microscopy; FRET; single particle tracking; membrane rafts; plasma membrane; lipids
Categories
Funding
- GEN-AU project of the Austrian Federal Ministry for Science and Research
- Austrian Science Fund (FWF) [Y250-B10, I301-B12]
- FEBS
- Austrian Science Fund (FWF) [I 301, Y 250] Funding Source: researchfish
- Austrian Science Fund (FWF) [I301] Funding Source: Austrian Science Fund (FWF)
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The plasma membrane is still one of the enigmatic cellular structures. Although the microscopic structure is getting clearer, not much is known about the organization at the nanometre level. Experimental difficulties have precluded unambiguous approaches, making the current picture rather fuzzy. In consequence, a variety of different membrane models has been proposed over the years, on the basis of different experimental strategies. Recent data obtained via high-resolution single-molecule microscopy shed new light on the existing hypotheses. We thus think it is a good time for reviewing the consistency of the existing models with the new data. In this paper, we summarize the available models in ten propositions, each of which is discussed critically with respect to the applied technologies and the strengths and weaknesses of the approaches. Our aim is to provide the reader with a sound basis for his own assessment. We close this chapter by exposing our picture of the membrane organization at the nanoscale.
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