Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 367, Issue 1592, Pages 1102-1111Publisher
ROYAL SOC
DOI: 10.1098/rstb.2011.0209
Keywords
protein transport; protein trafficking; bacteriophage; secretion; Hcp; VgrG
Categories
Funding
- CNRS
- Agence National de la Recherche [ANR-10-JCJC-1303-03]
- Universite Aix-Marseille
- Marseille-Nice Genopole, IBiSA
- Fondation pour la Recherche Medicale [SPF20101221116, FRM DEQ2011-0421282]
- Agence Nationale de la Recherche (ANR) [ANR-10-JCJC-1303] Funding Source: Agence Nationale de la Recherche (ANR)
Ask authors/readers for more resources
Type VI secretion systems (T6SSs) are transenvelope complexes specialized in the transport of proteins or domains directly into target cells. These systems are versatile as they can target either eukaryotic host cells and therefore modulate the bacteria-host interaction and pathogenesis or bacterial cells and therefore facilitate access to a specific niche. These molecular machines comprise at least 13 proteins. Although recent years have witnessed advances in the role and function of these secretion systems, little is known about how these complexes assemble in the cell envelope. Interestingly, the current information converges to the idea that T6SSs are composed of two subassemblies, one resembling the contractile bacteriophage tail, whereas the other subunits are embedded in the inner and outer membranes and anchor the bacteriophage-like structure to the cell envelope. In this review, we summarize recent structural information on individual T6SS components emphasizing the fact that T6SSs are composite systems, adapting subunits from various origins.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available