Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 367, Issue 1607, Pages 3254-3263Publisher
ROYAL SOC
DOI: 10.1098/rstb.2011.0384
Keywords
memory; intracellular signalling; endocannabinoid system; cannabinoid receptor; CB1
Categories
Funding
- EMBO
- European Commission [GA-2010-267146]
- Marie Curie Actions
- Spanish Ministry of Education and Culture
- La Marato de TV3 [090910]
- Spanish Ministry of Science and Innovation [SAF2009-07309, SAF2011-29864]
- Instituto de Salud Carlos III [RD06/0001/0001]
- Plan Espanol para el Estimulo de la Economia y el Empleo (PLAN E)
- Generalitat de Catalunya [SGR-2009-00731]
- Institucio Catalana de Recerca i Estudis Avancats (ICREA) Academia
Ask authors/readers for more resources
Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds modulate a number of signalling pathways critically implicated in the deleterious effect of cannabinoids on learning and memory. Thus, the involvement of the mammalian target of rapamycin pathway and extracellular signal-regulated kinases, together with their consequent regulation of cellular processes such as protein translation, play a critical role in the amnesic-like effects of cannabinoids. In this study, we summarize the cellular and molecular mechanisms reported in the modulation of cognitive function by the endocannabinoid system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available