Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 366, Issue 1561, Pages 9-16Publisher
ROYAL SOC
DOI: 10.1098/rstb.2010.0276
Keywords
daf-2; daf-16; FOXO; history; insulin; IFG-1
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Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here.
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