Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 365, Issue 1544, Pages 1195-1201Publisher
ROYAL SOC
DOI: 10.1098/rstb.2009.0282
Keywords
adaptation; beneficial mutations; dominance; extreme value theory; X chromosome
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Funding
- National Institutes of Health [GM51 932]
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The population genetic study of advantageous mutations has lagged behind that of deleterious and neutral mutations. But over the past two decades, a number of significant developments, both theoretical and empirical, have occurred. Here, I review two of these developments: the attempt to determine the distribution of fitness effects among beneficial mutations and the attempt to determine their average dominance. Considering both theory and data, I conclude that, while considerable theoretical progress has been made, we still lack sufficient data to draw confident conclusions about the distribution of effects or the dominance of beneficial mutations.
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