Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 363, Issue 1495, Pages 1387-1392Publisher
ROYAL SOC
DOI: 10.1098/rstb.2007.2256
Keywords
embryo; Xenopus; induction; morphogens; activin
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Funding
- Medical Research Council [G0300723B] Funding Source: researchfish
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In this article, we describe the mechanisms by which morphogens in the Xenopus embryo exert their long-range effects. Our results are consistent with the idea that signalling molecules such as activin and the nodal-related proteins traverse responding tissue not by transcytosis or by cytonemes but by movement through the extracellular space. We suggest, however, that additional experiments, involving real-time imaging of morphogens, are required for a real understanding of what influences signalling range and the shape of a morphogen gradient.
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