Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 363, Issue 1500, Pages 2143-2151Publisher
ROYAL SOC
DOI: 10.1098/rstb.2008.2267
Keywords
Forster resonance energy transfer; fluorescence resonance energy transfer; fluorescence protein; signal transduction
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Fluorescence probes based on the principle of Forster resonance energy transfer ( FRET) have shed new light on our understanding of signal transduction cascades. Among them, unimolecular FRET probes containing fluorescence proteins are rapidly increasing in number because these genetically encoded probes can be easily loaded into living cells and allow simple acquisition of FRET images. We have developed probes for small GTPases, tyrosine kinases, serine-threonine kinases and phosphoinositides. Images obtained with these probes have revealed that membrane protrusions such as nascent lamellipodia or neurites provide an active signalling platform in the growth factor-stimulated cells.
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