Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 363, Issue 1507, Pages 3201-3211Publisher
ROYAL SOC
DOI: 10.1098/rstb.2008.0101
Keywords
alcohol; genetic animal models; candidate genes
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Funding
- NIAAA NIH HHS [R01 AA012714, P50 AA010760, P60 AA010760, U01 AA013519, AA12714, AA10760, AA13519] Funding Source: Medline
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Neurogenetic studies of alcohol dependence have relied substantially on genetic animal models, particularly rodents. Studies of inbred strains, selectively bred lines and mutants bearing genes whose function has been targeted for over or under expression are reviewed. Studies focused on gene expression changes are the most recent contributors to this literature, and some genetic effects may work through epigenetic mechanisms. In a few instances, interesting parallels have been revealed between genetic risk in humans and studies in non-human animal models. Future approaches are likely to be increasingly complex.
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