Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
Volume 372, Issue 2021, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsta.2013.0389
Keywords
red blood cell; multi-scale modelling; dissipative particle dynamics
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Funding
- National Institutes of Health (NIH) grant [U01HL114476]
- new DOE Collaboratory on Mathematics for Mesoscopic Modeling of Materials (CM4)
- Direct For Biological Sciences
- Div Of Biological Infrastructure [1300426] Funding Source: National Science Foundation
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This study is partially motivated by the validation of a new two-component multi-scale cell model we developed recently that treats the lipid bilayer and the cytoskeleton as two distinct components. Here, the whole cell model is validated and compared against several available experiments that examine red blood cell (RBC) mechanics, rheology and dynamics. First, we investigated RBC deformability in a microfluidic channel with a very small cross-sectional area and quantified the mechanical properties of the RBC membrane. Second, we simulated twisting torque cytometry and compared predicted rheological properties of the RBC membrane with experimental measurements. Finally, we modelled the tank-treading (TT) motion of a RBC in a shear flow and explored the effect of channel width variation on the TT frequency. We also investigated the effects of bilayer-cytoskeletal interactions on these experiments and our simulations clearly indicated that they play key roles in the determination of cell membrane mechanical, rheological and dynamical properties. These simulations serve as validation tests and moreover reveal the capabilities and limitations of the new whole cell model.
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