Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
Volume 371, Issue 1995, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsta.2012.0368
Keywords
nitric oxide; NO donors; metal nitrosyls; polymer matrices; photochemotherapeutics
Categories
Funding
- National Science Foundation [CHE0553405, CHE-0957251, DMR-1105296]
- Direct For Mathematical & Physical Scien [1105296] Funding Source: National Science Foundation
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0957251] Funding Source: National Science Foundation
- Division Of Materials Research [1105296] Funding Source: National Science Foundation
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The discovery of nitric oxide (NO) as a signalling molecule in various physiological and pathological pathways has spurred research in the design of exogenous NO donors as drugs. In recent years, metal nitrosyls (NO complexes of metals) have been investigated as NO-donating agents. Results from our laboratory during the past few years have demonstrated that metal nitrosyls derived from designed ligands can deliver NO under the total control of light of various frequencies. Careful incorporation of these photoactive nitrosyls into polymer matrices has afforded a set of nitrosyl-polymer composites that can be used to make such NO delivery site-specific. The composite materials have shown excellent antineoplastic and antimicrobial actions in several in vitro experiments. This review highlights our key results in the context of recent developments in this area of NO donors that deliver NO on demand.
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