Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
Volume 370, Issue 1973, Pages 3924-3949Publisher
ROYAL SOC
DOI: 10.1098/rsta.2011.0049
Keywords
regenerative medicine; stem cells; manufacturing; automation; characterization
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Funding
- Engineering and Physical Sciences Research Council [EP/H028277/1] Funding Source: researchfish
- EPSRC [EP/H028277/1] Funding Source: UKRI
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Innovations in engineering applied to healthcare make a significant difference to people's lives. Market growth is guaranteed by demographics. Regulation and requirements for good manufacturing practice-extreme levels of repeatability and reliability-demand high-precision process and measurement solutions. Emerging technologies using living biological materials add complexity. This paper presents some results of work demonstrating the precision automated manufacture of living materials, particularly the expansion of populations of human stem cells for therapeutic use as regenerative medicines. The paper also describes quality engineering techniques for precision process design and improvement, and identifies the requirements for manufacturing technology and measurement systems evolution for such therapies.
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