Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
Volume 369, Issue 1955, Pages 4620-4643Publisher
ROYAL SOC
DOI: 10.1098/rsta.2011.0264
Keywords
optical imaging; molecular imaging; dynamic contrast; in vivo imaging
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Funding
- NIH (NIBIB) [1R43EB008627]
- NIH (NCI) [1U54CA126513]
- NIH (NINDS) [1R01NS063226, R21NS053684]
- Cambridge Research and Instrumentation (CRi)
- National Science Foundation
- Human Frontier Science Programme
- Rodriguez Family
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This paper provides an overview of optical imaging methods commonly applied to basic research applications. Optical imaging is well suited for non-clinical use, since it can exploit an enormous range of endogenous and exogenous forms of contrast that provide information about the structure and function of tissues ranging from single cells to entire organisms. An additional benefit of optical imaging that is often under-exploited is its ability to acquire data at high speeds; a feature that enables it to not only observe static distributions of contrast, but to probe and characterize dynamic events related to physiology, disease progression and acute interventions in real time. The benefits and limitations of in vivo optical imaging for biomedical research applications are described, followed by a perspective on future applications of optical imaging for basic research centred on a recently introduced real-time imaging technique called dynamic contrast-enhanced small animal molecular imaging (DyCE).
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