Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
Volume 367, Issue 1896, Pages 2257-2292Publisher
ROYAL SOC
DOI: 10.1098/rsta.2009.0056
Keywords
in silico heart model; multiscale modelling; cardiac electrical activity; individualized medicine; bidomain; parallel computing
Categories
Funding
- BBSRC [E003443]
- Marie Curie Fellowship [MC-OIF 040190]
- Austrian Science Fund [SFB F3210-N18]
- Research Councils UK
- EPSRC [GR/S720223/01, EP/F011628/1]
- European Commission Virtual Physiological Human initiative
- Microsoft
- MRC Career Development Award
- British Heart Foundation
- Austrian Science Fund (FWF) [F 3201] Funding Source: researchfish
- British Heart Foundation [PG/09/031/27221] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/F011628/1] Funding Source: researchfish
- Medical Research Council [G0700278] Funding Source: researchfish
- EPSRC [EP/F011628/1] Funding Source: UKRI
- MRC [G0700278] Funding Source: UKRI
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This paper presents methods to build histo-anatomically detailed individualized cardiac models. The models are based on high-resolution three-dimensional anatomical and/or diffusion tensor magnetic resonance images, combined with serial histological sectioning data, and are used to investigate individualized cardiac function. The current state of the art is reviewed, and its limitations are discussed. We assess the challenges associated with the generation of histo-anatomically representative individualized in silico models of the heart. The entire processing pipeline including image acquisition, image processing, mesh generation, model set-up and execution of computer simulations, and the underlying methods are described. The multifaceted challenges associated with these goals are highlighted, suitable solutions are proposed, and an important application of developed high-resolution structure-function models in elucidating the effect of individual structural heterogeneity upon wavefront dynamics is demonstrated.
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