Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
Volume 366, Issue 1879, Pages 3361-3380Publisher
ROYAL SOC
DOI: 10.1098/rsta.2008.0088
Keywords
transmural heterogeneity; cardiac electromechanics; computational modelling
Categories
Funding
- EPSRC [EP/D065666/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D065666/1] Funding Source: researchfish
- Howard Hughes Medical Institute [HHMI-56005681] Funding Source: Medline
- NCRR NIH HHS [P41 RR008605, RR08605, P41 RR008605-040006] Funding Source: Medline
- NHLBI NIH HHS [R01 HL096544] Funding Source: Medline
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The mechanical properties of myocardium vary across the transmural aspect of the left ventricular wall. Some of these functional heterogeneities may be related to differences in excitation contraction coupling characteristics that have been observed in cells isolated from the epicardial, mid-myocardial and endocardial regions of the left ventricle of many species, including canine. Integrative models of coupled myocyte electromechanics are reviewed and used here to investigate sources of heterogeneous electromechanical behaviour in these cells. The simulations (i) illustrate a previously unrecognized role of the transient outward potassium current in mechanical function and (ii) suggest that there may also exist additional heterogeneities affecting crossbridge cycling rates in cells from different transmural regions.
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