Journal
TUMOR BIOLOGY
Volume 36, Issue 11, Pages 8309-8316Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-015-3582-0
Keywords
Hepatocellular carcinoma; miR-582-5p; CDK1; AKT3; CyclinD1
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Funding
- Natural Science Foundation of China [30371394]
- Natural Science Fund of Hubei Province [2012FFA044]
- Health Department Found of Hubei Province [JX6B18]
- Public Service Platform Construction Projects of Wuhan Technology Bureau [2013060705010326]
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microRNAs play an important role in the progression of hepatocellular carcinoma (HCC). In this study, we found that miR-582-5p expression was downregulated in hepatoma tissues and HCC cell lines. Upregulation of miR-582-5p reduced colony number, inhibited cellular proliferation, and arrested cell cycle in G0/G1 phase. When miR-582-5p was inhibited, the colony number was increased and cellular proliferation and cell cycle were promoted. Further studies showed that miR-582-5p regulated the progression of HCC through directly inhibiting the expression of CDK1 and AKT3, and indirectly inhibiting the expression of cyclinD1.
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