Journal
PHARMACOPSYCHIATRY
Volume 42, Issue -, Pages S95-S101Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1214395
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Funding
- Bernstein Centre for Computational Neuroscience Berlin [01 GQ0411]
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An interplay of different neurotransmitter systems has been implicated in the development and maintenance of alcohol dependence. Here we focus on neuroadaptations in reward-related neurotransmitter systems and their impact on central processing of alcohol-associated and reward-indicating stimuli. We discuss genotype effects on cue-induced neuronal activation and present new computational methods based on machine learning to deal with complex genotype-phenotype interactions, e.g. between brain atrophy and genes associated with glutamatergic and dopaminergic neurotransmission.
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