Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 100, Issue 4, Pages 811-824Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2011.03.015
Keywords
Addiction; Synaptic plasticity; Memory; Learning; Extinction training; Calcium; MicroRNA; Homer
Funding
- National Health and Medical Research Council of Australia [566736, 454303]
- Australian Research Council [FT100100235]
- Australian Research Council [FT100100235] Funding Source: Australian Research Council
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Addiction is a chronic disorder characterised by repeated bouts of drug taking, abstinence and relapse. The addicted state may be in part due to drug-induced neuroadaptations in the mesocorticolimbic and corticostriatal pathways. Recently focus has been on the role of aberrant glutamate transmission and its contribution to the hierarchical control over these systems. This review will expand our current knowledge of the most recent advances that have been made in preclinical animal models that provide evidence that implicate metabotropic glutamate receptors (mGluRs) in contributing to the neuroadaptations pertinent to addiction, as well as the role of Homer proteins in regulating these responses. The recent discovery of receptor mosaics will be discussed which add an additional dimension to the complexity of understanding the mechanism of glutamate mediated behaviours. Finally this review introduces a new area related to glutamatergic responses, namely microRNAs, that may become pivotal in directing our future understanding of how to best target intervention strategies to prevent addictive behaviours. (C) 2011 Elsevier Inc. All rights reserved.
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